Indian Airlines operates daily flights to Hyderabad (New Delhi) @ 14.20 Hrs; Jet Air Ways operates daily flights except on Tuesdays to Hyderabad @ 13.50 Hrs. From Chennai airport to Tirupati: Use this route if you have little luggage and are comfortable walking for short distances (and want to try a cheaper, alternative route to Chennai Central). From Chennai airport, you can walk over to the local suburban railway station (Tirusulam, about 5 minutes away) and take a local train to Park Station (Rs. 7, about 30 minutes). Chennai Central is a 5-10 minute walk from Park Station. From Chennai Central, there are frequent long distance train services to Tirupati.
Tirupati is a major junction in South Central Railways. Indian Railways operates direct trains from near by metro cities - Bangalore, Chennai, Hyderabad and other major Railway stations to Tirupati. Trains can be boarded at nearby cities - Renigunta (10 km from Tirupati) and Gudur (100 km) as well. Frequent bus service is available between Tirupati, Renigunta and Gudur.
National Highway NH 205 passes through Renigunta and hence is accessible from Chennai (3-4hrs), Bangalore (5+ hours), Hyderabad (10-12 hours) and other nearby cities.